GW 9662
2-chloro-5-nitro-N-phenylbenzamide
CAS: 22978-25-2
Molecular Formula: C13H9ClN2O3
GW 9662 - Names and Identifiers
| Name | 2-chloro-5-nitro-N-phenylbenzamide |
| Synonyms | GW9662 CS-762 GW 9662 GW 9662 TIMTEC-BB SBB006523 2-CHLORO-5-NITROBENZANILIDE 2-chloro-5-nitro-N-phenylbenzamide 2-CHLORO-5-NITRO-N-PHENYLBENZAMIDE |
| CAS | 22978-25-2 |
| EINECS | 636-590-7 |
| InChI | InChI=1/C13H9ClN2O3/c14-12-7-6-10(16(18)19)8-11(12)13(17)15-9-4-2-1-3-5-9/h1-8H,(H,15,17) |
| InChIKey | DNTSIBUQMRRYIU-UHFFFAOYSA-N |
GW 9662 - Physico-chemical Properties
| Molecular Formula | C13H9ClN2O3 |
| Molar Mass | 276.68 |
| Density | 1.440±0.06 g/cm3(Predicted) |
| Melting Point | 158-159 °C (lit.) |
| Boling Point | 360.9±32.0 °C(Predicted) |
| Flash Point | 172°C |
| Solubility | Soluble in DMSO (26 mg/ml), methanol, 100% ethanol (10 mg/ml), DMF (~35 mg/ml), and 1: |
| Vapor Presure | 2.15E-05mmHg at 25°C |
| Appearance | solid |
| Color | white |
| pKa | 11.77±0.70(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Refractive Index | 1.676 |
| MDL | MFCD01215270 |
| Use | A selective, irreversible, and effective PPARγ antagonist that also acts as a FXR and PXR agonist. |
| In vitro study | GW9662 binds to Cys(285) on PPAR gamma, which is conserved among the three PPAR. GW9662 is a PPARγ antagonist used to inhibit adipocyte differentiation. GW9662 inhibits PPAR gamma activation and inhibits the growth of human breast cancer tumor cell lines (MCF7, MDA-MB-468, MDA-MB-231) with an IC50 of 20 μm -30 μm, the PPAR gamma agonist properties or PPAR gamma independent growth inhibition mechanism of GW9662 are indicated. The combination of Rosiglitazone(50 μm) and GW9662(10 μm) on MDA-MB-231 cells resulted in a statistically lower number of viable cells after 7 days. PPARγ1 ligand was able to inhibit RANKL-induced osteoclast formation in primary murine bone marrow (BMs) and RAW264.7 cells. Importantly, GW 9662(2 μm) reverses the inhibition of these ligands in a concentration-dependent manner. GW 9662(2 μm) acts on BMs, blocking IL-4 inhibition of osteoclast formation. GW 9662(1 μm) acts on RAW264.7 cells to inhibit the RANKL activation of NF-κB. GW9662(10 μm) acts on primary preadipocytes in patients with thyroid ophthalmopathy and inhibits hormone and agonist-induced adipocyte differentiation. |
| In vivo study | Pretreatment of rats with LPS(1 mg/kg, I. P.) significantly attenuated all markers of renal injury and dysfunction-induced ischemia/reperfusion (I/R) injury. Most notably, GW9662(1 mg/kg, I. P.) abolished the protective effect of LPS. |
GW 9662 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36 - Irritating to the eyes R43 - May cause sensitization by skin contact |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| HS Code | 29242990 |
GW 9662 - Reference
| Reference Show more | 1. [IF=5.279] Jing Zhou et al."Ginsenoside F2 Suppresses Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway."J Agr Food Chem. 2021;69(32):9299–9312 |
GW 9662 - Introduction
GW9662 is a selective PPAR antagonist, acting on PPARγ,IC50 is 3.3 nM, and acting on PPARγ is 100 to 1000 times more selective than acting on PPARα and PPARδ.
Last Update：2022-10-16 17:15:06
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Spot supply
Product Name: GW9662 Visit Supplier Webpage Request for quotationCAS: 22978-25-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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